منابع مشابه
HLA Diversity in the 1000 Genomes Dataset
The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation by sequencing at a level that should allow the genome-wide detection of most variants with frequencies as low as 1%. However, in the major histocompatibility complex (MHC), only the top 10 most frequent haplotypes are in the 1% frequency range whereas thousands of haplotypes are present at lower ...
متن کاملApplications of the 1000 Genomes Project resources
The 1000 Genomes Project created a valuable, worldwide reference for human genetic variation. Common uses of the 1000 Genomes dataset include genotype imputation supporting Genome-wide Association Studies, mapping expression Quantitative Trait Loci, filtering non-pathogenic variants from exome, whole genome and cancer genome sequencing projects, and genetic analysis of population structure and ...
متن کامل1000 Genomes on the Road to Personalized Medicine.
The recently announced 1000 Genomes Project is an international collaboration to sequence 1000 individuals in an effort to produce the most complete catalog of human genetic variation to date. Building on the International HapMap Project, the 1000 Genomes Project will utilize new sequencing technologies to catalog genetic variants that are present in the human population across most of the geno...
متن کاملSolving Amazons *
We present a method of exhaustively solving the popular combinatorial game Amazons in a parallel setting. The game has a high branching factor with high overlap, making it difficult to search in parallel. We exploit some structural properties of game positions to minimise game tree expansion, and use a parallel breadth-first search algorithm on the game tree. Throughput is maximised by allowing...
متن کاملExperiments in Computer Amazons
Amazons is a relatively new game with some similarities to the ancient games of chess and Go. The game has become popular recently with combinatorial games researchers as well as in the computer games community. Amazons combines global full-board with local combinatorial game features. In the opening and early middle game, the playing pieces roam freely across the whole board, but later in the ...
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ژورنال
عنوان ژورنال: Nature Biotechnology
سال: 2012
ISSN: 1087-0156,1546-1696
DOI: 10.1038/nbt0512-376